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Your Phone Number required. Your Email required. Your Message. Suite Rockville, MD Short Term Effects of Testosterone Replacement Therapy Studies show that men who receive testosterone replacement start to notice their sex drive rising after just three weeks. Diabetes For men who have diabetes, or pre-diabetes, testosterone replacement therapy may bring dramatic and rapid improvements.

Long Term Effects of Testosterone Replacement Therapy Although the first testosterone therapy effects appear quickly, you need to keep up with the course of treatment for an extended period of time to reap the full benefits.

Sexual Effects Your sex life should improve over time as you receive testosterone replacement therapy. What to Expect With Testosterone Replacement Therapy Every man has a unique reaction to testosterone replacement therapy. What If You Do Not See Results From Testosterone Replacement Therapy If you have been on testosterone replacement therapy for several weeks or months and you are not noticing improvements, see your doctor for advice.

Contact form. Phone: Potential for secondary exposure to testosterone; promptly discontinue if signs of virilization in children and women occurs until cause is identified. Children and women must avoid contact with unwashed or unclothed application sites. Evaluate for prostate cancer prior to and during therapy. Monitor hematocrit prior to initiation, at 3—6 months after starting therapy, then annually; if elevation occurs, withhold until acceptable level.

Pre-existing cardiac, renal, or hepatic disease. Possible sleep apnea in patients with obesity or chronic lung diseases. Monitor for venous thromboembolism; discontinue if suspected. This medicine is flammable until it dries on the skin.

Do not use it near heat, an open flame, or while smoking. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the medicine in a safe place. Funding No financial or other support was received for the preparation of this manuscript.

Acknowledgements Ines Gerhardt is thanked for creation of the figures. References Nieschlag E. Testosterone treatment comes of age: new options for hypogonadal men. Clinical Endocrinology. Association of specific symptoms and metabolic risks with serum testosterone in older men.

Journal of Clinical Endocrinology and Metabolism. The endocrinology of sexual arousal. Journal of Endocrinology. Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction. Androgen deficiency and hormone-replacement therapy. BJU International. Non-genomic actions of androgens. Frontiers in Neuroendocrinology.

Effect of testosterone on ex vivo vascular reactivity in man. Clinical Science. Testosterone dose—response relationships in healthy young men. American Journal of Physiology. Endocrinology and Metabolism. Development of models to predict anabolic response to testosterone administration in healthy young men.

Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. Testosterone and growth hormone improve body composition and muscle performance in older men.

Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. Journal of the American College of Cardiology. Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men.

Journal of the American Geriatrics Society. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study.

Adverse events associated with testosterone administration. New England Journal of Medicine. Exogenous testosterone T alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. The role of estrogens for male bone health. Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials.

Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. Journal of the American Medical Association. Androgen supplementation in eugonadal men with osteoporosis-effects of 6 months of treatment on bone mineral density and cardiovascular risk factors.

Vascular reactivity in hypogonadal men is reduced by androgen substitution. Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men. Aging Male. Effect of testosterone treatment on bone mineral density in men over 65 years of age. Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. Androgens and obesity. Current Opinion in Endocrinology, Diabetes, and Obesity. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors.

Effects of testosterone supplementation in the aging male. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Improvement of the metabolic syndrome and of non-alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate.

Testosterone deficiency, insulin resistance and the metabolic syndrome. Nature Reviews. Measurement site for waist circumference affects its accuracy as an index of visceral and abdominal subcutaneous fat in a Caucasian population. Journal of Nutrition. An exploratory study of the effects of 12 month administration of the novel long-acting testosterone undecanoate on measures of sexual function and the metabolic syndrome.

Archives of Andrology. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism. Journal of Endocrinological Investigation.

Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The efficacy and safety of testosterone undecanoate Nebido R in testosterone deficiency syndrome in Korean: a multicenter prospective study. Journal of Sexual Medicine. Androgen treatment of abdominally obese men.

Obesity Research. Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone.

Journal of Andrology. Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. Testosterone replacement therapy restores normal ghrelin in hypogonadal men. Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a month, randomized, double-blind, placebo-controlled study.

Effect of testosterone on insulin sensitivity in men with hypogonadotropic hypogonadism. Endocrine Practice. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.

Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: the Tromso study. Nutrition, Metabolism, and Cardiovascular Diseases. Low fasting triglycerides: hallmark of the healthy large hip? Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. Dose—response effect of elevated plasma free fatty acid on insulin signaling.

Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. Journal of Clinical Investigation. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.

Glucose-dependent insulinotropic polypeptide GIP stimulates transepithelial glucose transport. Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study.



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