What is lu us

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ET by Ruth Mantell. ET by Carla Mozee. Symptoms include headaches, dizziness, depression , memory disturbances, vision problems, seizures, stroke , or changes in behavior. Blood vessels : Vasculitis, or inflammation of the blood vessels, can occur.

This can affect circulation. Blood : Lupus can cause anemia, leukopenia a decreased number of white blood cells or thrombocytopenia a decrease in the number of platelets in the blood, which assist in clotting. Heart : If inflammation affects the heart, it can result in myocarditis and endocarditis. It can also affect the membrane that surrounds the heart, causing pericarditis. Chest pain or other symptoms may result.

Endocarditis can damage the heart valves, causing the valve surface to thicken and develop. This can result in growths that can lead to heart murmurs. Infection : Infection becomes more likely because both lupus and its treatments weaken the immune system.

Common infections include urinary tract infections , respiratory infections, yeast infections, salmonella, herpes , and shingles. Bone tissue death : This occurs when there is low blood supply to a bone. Tiny breaks can develop in the bone. Eventually, the bone may collapse. It most commonly affects the hip joint. Pregnancy complications : Women with lupus have a higher risk of pregnancy loss, preterm birth, and preeclampsia , a condition that includes high blood pressure. To reduce the risk of these complications, doctors often recommend delaying pregnancy until lupus has been under control for at least 6 months.

The American College of Rheumatology use a standard classification scheme to confirm a diagnosis. On the other hand, some blood tests can lead to overdiagnosis, because people without lupus can have the same antibodies as those with the condition.

Diagnosis can be difficult because of the varied symptoms that may resemble symptoms of other illnesses. The doctor will ask about symptoms, carry out a physical examination, and take a personal and family medical history. They will also consider the 11 criteria mentioned above.

Biomarkers are antibodies, proteins, genetic, and other factors that can show a doctor what is happening in the body or how the body is responding to treatment.

They are useful because they can indicate if a person has a condition even when there are no symptoms. Lupus affects individuals in different ways. This makes it difficult to find reliable biomarkers. However, a combination of blood tests and other investigations can help a doctor to confirm a diagnosis. Blood tests can show whether certain biomarkers are present, and biomarkers can give information about which autoimmune disease, if any, a person has.

Around 95 percent of people with lupus will have a positive result in the ANA test. However, some people test positive for ANA, but they do not have lupus. Other tests must confirm the diagnosis. Antiphospholipid antibodies APLs are a type of antibody directed against phospholipids.

APLs are present in up to 50 percent of people with lupus. People without lupus can also have APLs. A person with APLs may have a higher risk of blood clots, stroke, and pulmonary hypertension. There is also a higher risk of pregnancy complications, including a loss of pregnancy. Around 70 percent of people with lupus have an antibody known as the anti-DNA antibody.

The result is more likely to be positive during a flare-up. Fewer than 1 percent of people without lupus have this antibody.

If the test is positive, it may mean that a person has a more serious form of lupus, such as lupus nephritis, or kidney lupus. Around 20 percent of people with lupus have an antibody to Sm, a ribonucleoprotein that is present in the nucleus of a cell. It is present in fewer than 1 percent of people without lupus, and it is rare in those with other rheumatic diseases. For this reason, a person with anti-sm antibodies is likely to have lupus.

It is not usually present with kidney lupus. Around 25 percent of people with lupus have anti-U1RNP antibodies, and fewer than 1 percent of people without lupus have them. They are present in small amount in about 15 percent of people without lupus, and they can occur with other rheumatic conditions, such as rheumatoid arthritis. If a mother has anti-Ro and anti-La antibodies, there is a higher chance that a baby born to her will have neonatal lupus. Antibodies to histones are proteins that play a role in the structure of DNA.

People with drug-induced lupus usually have them, and people with SLE may have them. However, they do not necessarily confirm a diagnosis of lupus. Serum blood complement test A serum complement test measures the levels of proteins that the body consumes when inflammation takes place.

If a person has low complement levels, this suggests that inflammation is present in the body and that SLE is active. Urine tests can help to diagnose and monitor the effects of lupus on the kidneys. The presence of protein, red blood cells, white blood cells, and cellular casts can all help to show how well the kidneys are working. For some tests, only one sample is necessary. For others, the person may need to collect samples over 24 hours.

The doctor may also request biopsies , usually of the skin or kidneys, to check for any damage or inflammation. Ongoing tests can show how lupus continues to affect a person or how well their body is responding to treatment. There is currently no cure for lupus, but people can manage their symptoms and flares with lifestyle changes and medication.

The exact treatment will depend on how lupus affects the individual. Without treatment, flares can occur that may have life-threatening consequences. Apart from medication, the following may help to relieve pain or reduce the risk of a flare:. Some people use the supplement thunder-god vine.

Recent national incidence estimates are not available for SLE. National incidence data are difficult to obtain because it is relatively expensive to capture all diagnosed cases reliably learn more about SLE prevalence and incidence above and the year of onset is hard to determine slowly developing, non-specific symptoms and signs , so resource-intense studies must be done in small areas.

Annual incidence estimates were much higher for women than men in Michigan 9. Causes of premature death associated with SLE are mainly active disease, organ failure e. Using death certificates for US residents, SLE was identified as the underlying cause of death for an average of 1, deaths per year from — CDC has previously funded five lupus registries and the development of a public health agenda Cdc-pdf External to guide public health efforts.

Currently, CDC is funding work on several SLE-relevant activities, such as three follow-up studies and research for self-management. For more information, visit the CDC-funded activities page. SLE is the most common and most serious type of lupus. Other types of lupus include the following:. Cutaneous lupus skin lupus is lupus that affects the skin in the form of a rash or lesions.

This type of lupus can occur on any part of the body, but usually appears where the skin is exposed to sunlight. Drug-induced lupus is similar to SLE, but occurs as the result of an overreaction to certain medications. Symptoms usually occur 3 to 6 months after starting a medication, and disappear once the medicine is stopped.

Neonatal lupus occurs when an infant passively acquires auto-antibodies from a mother with SLE. Top of Page. Section Navigation. Facebook Twitter LinkedIn Syndicate. Minus Related Pages. On This Page. What is SLE? How serious is SLE? What causes SLE? What are the signs and symptoms? What are the complications? Can I have a healthy pregnancy?